Ingredients

GINKGO BILOBA

Used In

logic

Key Focus Areas

Processing
Visual Memory
Blood Flow

Found in

Extracted from the leaves of the Ginkgo Biloba tree, which is native to China.

Why we use it

Ginkgo Biloba has been studied for it's impact on dopamine in the prefrontal cortex. Increasing dopamine supports cognitive flexibility.

Highlighted Studies

Study 1 - Effects of Ginkgo biloba extract on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity

Study 2 - Neuroregulatory role of ginkgolides

Study 3 - A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract

ALPHA GPC

Used In

clarity

creativity

Key Focus Areas

Memory
Neurogenesis
Neuroprotection

Found in

AlphaGrain™Alpha GPC 50% is a standardized form of Alpha GPC. It can be produced synthetically or naturally derived from some food sources, like eggs, dairy, meat, and fish.

Why we use it

Alpha GPC is a useable source of choline, which is used in the brain to make acetylcholine. Acetylcholine is the neurotransmitter primarily associated with learning and memory.

Highlighted Studies

Study 1 - The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility

Study 2 - Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data

Study 3 - Quantitative electroencephalography changes in patients with mild cognitive impairment after choline alphoscerate administration

CITICOLINE

Used In

energy

Key Focus Areas

Learning
Neuroprotection
Memory

Found in

Citicoline is found in high concentrations in soybeans, animal products, eggs and fish.

Why we use it

Citicoline supports healthy cognitive function and is the building block of Acetylcholine a key neurotransmitter associated with learning and memory.

Highlighted Studies

Study 1 - Citicoline and Memory Function

Study 2 - Citicoline and verbal memory in aging

Study 3 - Citicoline and the treatment of cognitive impairment

THEOBROMINE

Used In

logic

Key Focus Areas

Alertness
Energy
Neuroprotection

Found in

Theobromine is the primary alkaloid found in Cocoa.

Why we use it

Theobromine stimulates the release of dopamine and norepinephrine, which help maintain alertness and healthy energy levels. Theobromine is a molecule similar to caffeine, but has a slower onset and longer lasting effect.

Highlighted Studies

Study 1 - Methylxanthines: the psycho-pharmacologically active constituents of chocolate

Study 2 - A study on Theobromine, and the up-regulation of cerebral brain-derived neurotrophic factor

Study 3 - A study on Theobromine and working memory (CaMKII/CREB/BDNF Pathway)

L-PHENYLALANINE

Used In

motivation

Key Focus Areas

Memory
Motivation
Attention

Found in

L-Phenylalanine is an essential amino acid found in high concentrations in meat, fish, eggs, soybeans, and cheese.

Why we use it

L-Phenylalanine is an amino acid that is a precursor of the excitatory neurotransmitters dopamine and norepinephrine.

Highlighted Studies

Study 1 - Effects of tyrosine/phenylalanine depletion on electrophysiological correlates of memory

Study 2 - A study on DL-phenylalanine

Study 3 - Behavioral and cognitive effects of tyrosine intake

MANGO LEAF

Used In

energy

Key Focus Areas

Energy
Accuracy
Visual Memory

Found in

Zynamite® is a standardized extract from Mangifera indica, commonly known as mango leaves.

Why we use it

Mangifera indica has been shown to support performance accuracy, information processing and memory in select clinical trials. Mango leaf extracts have been used for centuries to support healthy energy levels.

Highlighted Studies

Study 1 - Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function

Study 2 - Analysis of phenolic compounds in mango leaves varieties

Study 3 - Central nervous system activities of extract Mangifera indica L

METHYLLIBERINE

Used In

motivation

Key Focus Areas

Alertness
Memory
Energy

Found in

Dynamine™ is a standardized molecule naturally found in coffee beans, tea, guarana, cocoa, and yerba mate.

Why we use it

Studies show that Dynamine™ has been found to support alertness, and maintain energy levels. Dynamine™ is an alkaloid compound that is structurally similar to caffeine.

Highlighted Studies

Study 1 - Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial

Study 2 - Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine®

Study 3 - A Combination of Caffeine, TeaCrine (Theacrine), and Dynamine (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers

LION'S MANE MUSHROOM

Used In

clarity

Key Focus Areas

Memory
Learning
Neuroprotection

Found in

Lion’s Mane Mushrooms are native to Northern United States and Canada.

Why we use it

Studies have shown Lion's Mane may increase levels of Brain Derived Neutropic Factor. It has been studied for its ability to maintain cognitive performance and support memory.

Highlighted Studies

Study 1 - Study on the effects of the mushroom Yamabushitake (Hericium erinaceus)

Study 2 - A study on Hericium erinaceus impact on Mood and Sleep

Study 3 - Study on cognitive functions by oral intake of Hericium erinaceus

CAMELLIA SINENSIS TEA LEAF

Used In

clarity

Key Focus Areas

Neuroprotection
Blood Flow
Mood

Found in

Epicatechin is a molecule found in high concentration in green tea and dark chocolate.

Why we use it

Studies have shown Epicatechin to be a potent antioxidant that can pass the blood brain barrier. Antioxidants help neutralize oxidative stress which supports healthy cellular function.

Highlighted Studies

Study 1 - The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow

Study 2 - Green tea effects on cognition, mood and human brain function: A systematic review

Study 3 - Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases

VITAMIN B12

Used In

motivation

Key Focus Areas

Energy
Nerve Health
Cellular Function

Found in

Methylcobalamin is a bioavailable form of Vitamin B12 that can be man-made or found in high concentrations of animal protein.

Why we use it

Vitamin B12 is known to support energy levels and is essential for nerve health. Studies have shown deficiencies in B12 can lead to decreased cognitive function.*

Highlighted Studies

Study 1 - Effects of Vitamin B12 Supplementation on Cognitive Function and Fatigue

Study 2 - Neurological symptoms of vitamin B12 deficiency

Study 3 - Vitamin B12 deficiency: case report and review of literature

AGMATINE SULFATE

Used In

creativity

Key Focus Areas

Mood
Neuroprotection
Stress

Found in

Agmatine Sulfate is naturally produced by bacteria, plants, and human cells.

Why we use it

Agmatine Sulfate, derived from amino acid L-arginine, has been studied for its ability to modulate NMDA receptors.*

Highlighted Studies

Study 1 - Neuroprotective offerings by agmatine

Study 2 - Agmatine, a potential novel therapeutic strategy

Study 3 - Neuroprotective Role of Agmatine in Neurological Diseases

THEACRINE

Used In

energy

Key Focus Areas

Energy
Motivation
Processing

Found in

TeaCrine® is a standardized alkaloid naturally found in the plant Cupuaçu, related to the cacao tree.

Why we use it

Research indicates TeaCrine® increases activity in the nucleus accumbens (NAc) region of the brain, which is believed to support motivation and and maintain healthy cognitive function.

Highlighted Studies

Study 1 - Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

Study 2 - Cognitive Performance and Mood Following Ingestion of a Theacrine

Study 3 - The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players

N-ACETYL CYSTEINE

Used In

energy

Key Focus Areas

Cellular function
Neuroprotection
Mood

Found in

Cysteine is found in most high-protein foods, like turkey, yogurt, eggs, sunflower seeds and legumes.

Why we use it

Studies have shown NAC may increase levels of glutathione, which help regulate the neurotransmitter glutamate, as well as support detoxification.

Highlighted Studies

Study 1 - A study on N-Acetyl Cysteine and it's function as a Fast-Acting Antioxidant

Study 2 - Therapeutic potential of N-acetylcysteine

Study 3 - A study on N-acetylcysteine and selective protection of cerebellar granule cells

INDIAN TRUMPET TREE

Used In

energy

Key Focus Areas

Memory
Motivation
Neuroprotection

Found in

Sabroxy®is a standardized extract from the bark of Oroxylum Indicum, the Indian trumpet tree.

Why we use it

Oroxylum Indicum has been traditionally used in Ayurvedic medicine for centuries. Studies suggest it may improve cognitive function and memory.*

Highlighted Studies

Study 1 - Effects of an Oroxylum indicum Extract (Sabroxy®) on Cognitive Function in Adults With Self-reported Mild Cognitive Impairment

Study 2 - Oroxylum indicum (L.) extract and human neuroblastoma

Study 3 - Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology

FORSKOLIN

Used In

motivation

Key Focus Areas

Neuroprotection
Blood Flow
Cellular function

Found in

Made from the root of a plant in the mint family, Forskolin grows in Nepal, India, and Thailand.

Why we use it

Studies have shown that Forskolin increases cellular levels of a molecule called cyclic adenosine monophosphate, or cAMP. Forskolin maintains healthy blood flow to the brain.

Highlighted Studies

Study 1 - Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function

Study 2 - Body composition and hormonal adaptations associated with forskolin consumption

Study 3 - Effects of forskolin on cerebral blood flow

PHOSPHATIDYLSERINE

Used In

logic

Key Focus Areas

Memory
Stress
Attention

Found in

A naturally occurring phospholipid, our Phosphatidylserine is from sunflowers.

Why we use it

Studies have shown this supplement to maintain memory formation and support the body's cortisol response.*

Highlighted Studies

Study 1 - The effect of phosphatidylserine administration on memory

Study 2 - Effects of phosphatidylserine in age-associated memory impairment

Study 3 - Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients

ARTICHOKE

Used In

motivation

Key Focus Areas

Blood Flow
Processing
Stress

Found in

Artichoke leaves and roots.

Why we use it

Studies have shown Artichoke extract blocks an enzyme called phosphodiesterase IV which supports healthy blood flow. Flavonoids like those found in Artichoke extract have antioxidant properties.

Highlighted Studies

Study 1 - The role of luteolin in cognitive health

Study 2 - Phosphodiesterase Inhibitors and Neuroprotection

Study 3 - A study on Luteolin, long-term potentiation and cognitive function

N-ACETYL L-TYROSINE

Used In

energy

Key Focus Areas

Alertness
Attention
Memory

Found in

High concentrations in animal protein, dairy products, and whole grains.

Why we use it

Tyrosine is an amino acid precursor to the excitatory neurotransmitters, dopamine and norepinephrine.

Highlighted Studies

Study 1 - Influence of nutritional tyrosine on cognition and functional connectivity

Study 2 - Effect of tyrosine supplementation

Study 3 - A study on Tyrosine benefits cognitive and psychomotor performance during body cooling

PANAX GINSENG

Used In

creativity

Key Focus Areas

Memory
Energy
Neuroprotection

Found in

GS15-4® is a standardized extract from Panax Ginseng, a root native to Eastern Russian, Northeast China, and the Korean Peninsula.

Why we use it

Studies have shown the active components of Panax Ginseng, Ginsenosides, to support the expression of acetylcholine in the brain, which maintains learning and memory.*

Highlighted Studies

Study 1 - Benefits of American Ginseng on mood and cognition in healthy young adults

Study 2 - Mechanism of action of Panax ginseng

Study 3 - Panax ginseng enhances cognitive performance

HIGH DHA ALGAE

Used In

logic

Key Focus Areas

Cellular Function
Processing
Memory

Found in

AvailOm® is a standardized form of DHA, an omega-3 fatty acid derived from algae.

Why we use it

DHA is a complex fatty acid molecule crucial for it's role in supporting neurological development and maintaining brain health.

Highlighted Studies

Study 1 - Omega-3 supplementation improves cognition and modifies brain activation in young adults

Study 2 - Dietary DHA and health: cognitive function ageing

Study 3 - Supplementation with DHA and the psychological functioning of young adults

ASHWAGANDHA ROOT

Used In

creativity

Key Focus Areas

Memory
Attention
Neuroprotection

Found in

KSM-66® is a standardized extract found in high concentrations of the Ashwagandha root.

Why we use it

Ashwagandha modulates our body’s stress response to cortisol. This non-sedating modulation supports calm in stressful situations. Ashwagandha roughly translates to the “smell and strength of a horse!”

Highlighted Studies

Study 1 - Clinical evaluation of the pharmacological impact of ashwagandha root extract

Study 2 - Efficacy and Safety of Ashwagandha

Study 3 - Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial

DIHYDROXYFLAVONE

Used In

clarity

Key Focus Areas

Neuroprotection
Neurogenesis
Cellular Function

Found in

7,8 Dihydroxyflavone is a flavone molecule found in the plants Godmania aesculifolia, Tridax procumbens, and in Primula tree leaves.

Why we use it

Studies have shown 7,8 Dihydroxyflavone can cross the blood brain barrier and bind to TrkB receptors. TrkB is a receptor for brain-derived neurotrophic factor.*

Highlighted Studies

Study 1 - 7,8-dihydroxyflavone as a promising nutraceutical

Study 2 - 7,8-Dihydroxyflavone Mechanism of Action

Study 3 - 7,8-Dihydroxyflavone and Neurodevelopment

URIDINE MONOPHOSPHATE

Used In

logic

Key Focus Areas

Memory
Neuroprotection
Mood

Found in

Uridine is found in foods such as fish, walnuts, broccoli, and tomatoes.

Why we use it

Uridine is needed to build the cell membrane of our nerve cells and produce choline. It also supports neurotrophic factors BDNF and NGF, which maintains healthy cognitive function.*

Highlighted Studies

Study 1 - Triacetyluridine (TAU) study on brain pH

Study 2 - Oral uridine and neuroprotection

Study 3 - Study on Oral uridine pro-drug PN401

BACOPA MONNIERI

Used In

logic

Key Focus Areas

Memory
Neuroprotection
Learning

Found in

Synapsa® is a standardized extract of the Bacopa Monnieri plant. It has a wide range of active constituents that contribute to its therapeutic properties.

Why we use it

Bacopa is one of the most studied nootropics. Traditionally, Bacopa Monnieri Extract is used to support cognitive function as well as overall brain health.

Highlighted Studies

Study 1 - Effects of a standardized Bacopa monnieri extract on cognitive performance

Study 2 - The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials

Study 3 - Bacopa monnieri on memory performance

SAFFRON

Used In

confidence

Key Focus Areas

Mood
Neuroprotection
Processing

Found in

Affron® is a standardized extract from saffron, originating from the flower Crocus Sativus.

Why we use it

Saffron has been studied for it's ability to modulate the amount of serotonin available in the brain. Serotonin is a primary neurotransmitter involved in mood regulation. Saffron is the world's most expensive spice. The flowers must be hand picked, and it takes approximately 70,000 flowers to harvest a single pound of saffron stigmas.

Highlighted Studies

Study 1 - Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial

Study 2 - A meta-analysis of randomized clinical trials

Study 3 - Saffron: A Natural Potent Antioxidant

MAGNESIUM BISGLYCINATE

Used In

confidence

Key Focus Areas

Neuroprotection
Neuroplasticity
Mood

Found in

A highly absorbable form of magnesium that has been shown to activate the glycine receptor, an inhibitory neurotransmitter that promotes calming effects on the brain and body.

Why we use it

Studies have shown magnesium may support mood, sleep, and fight oxidative stress.

Highlighted Studies

Study 1 - Magnesium in drug dependences

Study 2 - The effect of vitamin D and magnesium supplementation

Study 3 - Study on Magnesium supplementation

SAGE

Used In

confidence

Key Focus Areas

Neuroprotection
Mood
Memory

Found in

Salvia Officinalis, more commonly known as Sage, is an herb native to the Middle East and Mediterranean areas. This herb has a long history of use in traditional medicine.

Why we use it

Sage has studied as an antioxidant and for its ability to modulate GABA neurotransmission. GABA is the neurotransmitter known for calm and feelings of relaxation.*

Highlighted Studies

Study 1 - An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers

Study 2 - Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood and performance on a psychological stressor battery

Study 3 - Differential effects of the aromas of Salvia species on memory and mood

SCELETIUM TORTUOSUM

Used In

creativity

confidence

Key Focus Areas

Blood Flow
Neuroplasticity
Mood

Found in

Zembrin® is a standardized extract of the South African plant Sceletium Tortuosum.

Why we use it

Studies have shown Zembrin® supports serotonin which regulates mood.

Highlighted Studies

Study 1 - Sceletium tortuosum (Zembrin® ) ameliorates experimentally induced anxiety in healthy volunteers

Study 2 - Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus

Study 3 - Ergogenic Effects of 8 Days of Sceletium Tortuosum Supplementation on Mood, Visual Tracking, and Reaction

MAGNOLIA BARK

Used In

confidence

Key Focus Areas

Memory
Neuroprotection
Learning

Found in

DHH-B is a natural derivative of Magnolia Tree Bark and has been used traditionally in medicinal practices throughout much of Southeast Asia.

Why we use it

Magnolia Bark has been studied for it's ability to support the body’s stress response to cortisol. Cortisol is known as the body's stress hormone.

Highlighted Studies

Study 1 - Honokiol: A review of its pharmacological potential and therapeutic insights

Study 2 - The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms

Study 3 - Anxiolytic-like effect of dihydrohonokiol following behavioural and biochemical assessments

ASHWAGANDHA LEAF & ROOT

Used In

confidence

Key Focus Areas

Mood
Neuroprotection
Stress

Found in

Shoden® is the standardized, high potency extract from the leaves and roots of the Ashwagandha plant.

Why we use it

Shoden® is a highly bioavailable adaptogen. Adaptogens mimic the body’s own stress-reducing hormones, increasing the body’s ability to recover from stress and feeling of balance.

Highlighted Studies

Study 1 - Efficacy and Safety of Ashwagandha Root Extract in Improving Memory and Cognitive Functions

Study 2 - An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study

Study 3 - Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study

CAFFEINE

Used In

energy

clarity

creativity

motivation

logic

confidence

Key Focus Areas

Alertness
Energy
Attention

Found in

Coffee, tea, cacao, yerba mate, and guarana berries.

Why we use it

Caffeine blocks adenosine molecules from their receptor. When this occurs more dopamine and norepinephrine are released from our neurons. Caffeine is commonly associated with maintaining healthy energy levels.

Highlighted Studies

Study 1 - Effects of Caffeine on reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep

Study 2 - Study on the combination of L-theanine and caffeine across cognitive performance and subjective alertness

Study 3 - Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects

L-THEANINE

Used In

energy

clarity

creativity

logic

confidence

motivation

Key Focus Areas

Alertness
Stress
Reaction time

Found in

L-Theanine is found in fairly high concentrations in green tea, and can also be found in several mushroom species.

Why we use it

L-Theanine has been taken alongside caffeine for centuries to minimize jitters, so we include it in our caffeinated formulations.

Highlighted Studies

Study 1 - L-Theanine and the psychological and physiological stress responses

Study 2 - Impact of the combination of L-theanine and caffeine on cognitive performance and subjective alertness

Study 3 - The effects of L-theanine, caffeine and their combination on cognition and mood

Ingredients with purpose.

GINKGO BILOBA

ALPHA GPC

CITICOLINE

THEOBROMINE

L-PHENYLALANINE

MANGO LEAF

METHYLLIBERINE

LION'S MANE MUSHROOM

CAMELLIA SINENSIS TEA LEAF

VITAMIN B12

AGMATINE SULFATE

THEACRINE

N-ACETYL CYSTEINE

INDIAN TRUMPET TREE

FORSKOLIN

PHOSPHATIDYLSERINE

ARTICHOKE

N-ACETYL L-TYROSINE

PANAX GINSENG

HIGH DHA ALGAE

ASHWAGANDHA ROOT

DIHYDROXYFLAVONE

URIDINE MONOPHOSPHATE

BACOPA MONNIERI

SAFFRON

MAGNESIUM BISGLYCINATE

SAGE

SCELETIUM TORTUOSUM

MAGNOLIA BARK

ASHWAGANDHA LEAF & ROOT

CAFFEINE

L-THEANINE

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